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Smg-2 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O76512
Clone Names 6022404
Additional Information
Other Names Regulator of nonsense transcripts 1, 364-, ATP-dependent helicase smg-2, Nonsense mRNA reducing factor 1, Up-frameshift suppressor 1 homolog, smg-2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1970a was selected from the N-term region of human Smg-2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name smg-2
Function RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an smg-2-3-4 surveillance complex is believed to activate NMD (By similarity).
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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Background

Smg-2 eliminates the production of nonsense-containing RNAs. This protein is phosphorylated probably by smg-1. Smg-3 and smg-4 are required for phosphorylation.

References

Grimson, A. et al. Mol Cell Biol. 2004. 24(17):7483-90. Domeier, ME et al. Science. 2000. 289(5486):1928-31. Page, MF et al. Mol Cell Biol. 1999. 19(9):5943-51.

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$ 277.78
Cat# BP1970a
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Availability: 2 weeks
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