|Other Names||Alpha-1, 3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I, GNT-I, GlcNAc-T I, MGAT1, GGNT1, GLCT1, GLYT1, MGAT|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2406a was selected from the N-term region of human MGAT1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||GGNT1, GLCT1, GLYT1, MGAT|
|Function||Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein. Cytoplasm, perinuclear region. Note=Co-localizes with BRI3 isoform 1 at the perinuclear region.|
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Provided below are standard protocols that you may find useful for product applications.
There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. MGAT1 (UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I) is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis.
Tan, J., et al., Eur. J. Biochem. 231(2):317-328 (1995).Kumar, R., et al., Glycobiology 2(4):383-393 (1992).Hull, E., et al., Biochem. Biophys. Res. Commun. 176(2):608-615 (1991).Kumar, R., et al., Proc. Natl. Acad. Sci. U.S.A. 87(24):9948-9952 (1990).Yip, B., et al., Biochem. J. 321 (Pt 2), 465-474 (1997).
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