CACNA2D1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P54289 |
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Clone Names | 90904001 |
Gene ID | 781 |
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Other Names | Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-gated calcium channel subunit alpha-2/delta-1, Voltage-dependent calcium channel subunit alpha-2-1, Voltage-dependent calcium channel subunit delta-1, CACNA2D1, CACNL2A, CCHL2A, MHS3 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8699a was selected from the N-term region of human CACNA2D1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CACNA2D1 |
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Synonyms | CACNL2A, CCHL2A, MHS3 |
Function | The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel (PubMed:35293990). Plays an important role in excitation-contraction coupling (By similarity). |
Cellular Location | Membrane; Single-pass type I membrane protein. Cell membrane |
Tissue Location | Isoform 1 is expressed in skeletal muscle. Isoform 2 is expressed in the central nervous system. Isoform 2, isoform 4 and isoform 5 are expressed in neuroblastoma cells. Isoform 3, isoform 4 and isoform 5 are expressed in the aorta. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CACNA2D1 is a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits.
References
Williams,M.E., et.al., Neuron 8 (1), 71-84 (1992)Chaudhuri,D., et.al., J. Gen. Physiol. 129 (5), 385-401 (2007)
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