|Other Names||Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-gated calcium channel subunit alpha-2/delta-1, Voltage-dependent calcium channel subunit alpha-2-1, Voltage-dependent calcium channel subunit delta-1, CACNA2D1, CACNL2A, CCHL2A, MHS3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8699a was selected from the N-term region of human CACNA2D1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CACNL2A, CCHL2A, MHS3|
|Function||The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation- contraction coupling (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Isoform 1 is expressed in skeletal muscle. Isoform 2 is expressed in the central nervous system. Isoform 2, isoform 4 and isoform 5 are expressed in neuroblastoma cells. Isoform 3, isoform 4 and isoform 5 are expressed in the aorta.|
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Provided below are standard protocols that you may find useful for product applications.
CACNA2D1 is a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits.
Williams,M.E., et.al., Neuron 8 (1), 71-84 (1992)Chaudhuri,D., et.al., J. Gen. Physiol. 129 (5), 385-401 (2007)
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