Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
rat CNTF Protein
Rat Ciliary Neurotrophic Factor, Recombinant,E. coli
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Storage | -20°C |
|---|---|
| Precautions | rat CNTF Protein is for research use only and not for use in diagnostic or therapeutic procedures. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
CNTF is a polypeptide trophic factor, member of the alpha-helical cytokine superfamily1. It was initially purified from the chick eye on the basis of its ability to promote survival of E8 chick ciliary ganglion neurons in culture2. CNTF is synthesized by glia both in the CNS and PNS3 and it has been demonstrated that CNTF is ubiquitously distributed in neurons and glia throughout the rodent brain4. CNTF effects are mediated by a tripartite receptor complex consisting of two signal-transducing subunits (leukemia inhibitory factor receptor, gp130) and a CNTF-specific ligand-binding-subunit (CNTFR)5.
CNTF can support the survival of many different cell populations within the PNS and the CNS6.in vitro, CNTF promotes proliferation and neuronal specifications in hippocampal neurons. in vivo, CNTF supports the viability of non-primate motor neurons7, induces sprouting of cholinergic motor neurons8 and delays neural degeneration in genetic models of motor neuron disease9. In addition, it is involved in the development stage of astrocytes and oligodendocytes10.
References
1 . Mufson, E.J.et al.(1999)Prog. Neurobiol. 57,451.
2 . Adler, R.et al.(1979)Science204,1434.
3 . Murphy, M.et al.(1997)Prog. Neurobiol. 52,355.
4 . Henderson, J.T. et al.(1994)Mol. Brain Res. 22,151.
5 . Stahl, N.et al. (1993) J. Biol. Chem.268, 7628.
6 . Richardson, P.M.(1994)Pharmacol. Ther. 63,187.
7 . Ip, N.Y. et al.(1991)J. Physiol. 85,123.
8 . Gurney, M.E.et al.(1992)J. Neurosci. 12,3241.
9 . Sendtner, M.et al.(1992)Nature358,502.
10 . Mayer, M.et al.(1994)Development120,143.
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Shipping Information
