Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
hβ-NGF Protein
Human β-Nerve Growth Factor, Recombinant,E. coli
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Storage | -20°C |
|---|---|
| Precautions | hβ-NGF Protein is for research use only and not for use in diagnostic or therapeutic procedures. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
The neurotrophins ("neuro" means nerve and "trophe" means nutrient) are a family of soluble, basic growth factors which regulate neuronal development, maintenance, survival and death in the CNS and the PNS.1NGF, the first member of the family to be discovered, was originally purified as a factor able to support survival of sympathetic and sensory spinal neurons in culture.2 It is synthesized and secreted by sympathetic and sensory target organs and provides trophic support to neurons as they reach their final target.3
Neurotrophin secretion increases in the nervous system following injury. Schwann cells, fibroblasts, and activated mast cells normally synthesize NGF constitutively, however direct trauma and induction of cytokines combine to increase neurotrophin production in these cells after injury.4
The structural hallmark of all the neurotrophins is the characteristic arrangement of the disulfide bridges known as the cysteine knot, which has been found in other growth factors such as Platelet-Dervied Growth Factor.5 There is a 95.8% homology between the rat and mouse forms, and a 85% homology between the human and mouse.
NGF has been shown to regulate neuronal survival, development function and plasticity.6Recently, involvement of NGF in processes not involving neuronal cells has been shown, such as asthma,7psoriasis8 and wound healing.9 The biological effects of NGF are mediated by two receptors: TrkA, which is specific for NGF, and p75NTR, which binds all the neurotrophins.10
References
1 . Roux, P. et al. (2002) Prog. Neurobiol.67, 203.
2 . Levi-Montalcini, R.(1966)Harvey Lect.60, 217.
3 . Farinas, I.et al.(1998)Neuron21, 325.
4 . Levi-Montalcini, R.et al. (1996) Trends Neurosci.19, 514.
5 . McDonald, N.Q.et al. (1991) Nature354, 411.
6 . Huang, E.J. and Reichardt, L.F.(2001)Annu. Rev. Neurosci.24, 677.
7 . Freund V. and Frossard, N.(1994)Prog. Brain Res.146, 335.
8 . Raychaudhuri, S.P. and Raychaudhuri, S.K.(2004)Prog. Brain Res.146, 433.
9 . Kawamoto, K. and Matsuda, H.(2004)Prog. Brain. Res.146,369.
10 . Teng, K.K. and Hempstead, B.L.(2004)Cell Mol. Life Sci.61, 35.
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Shipping Information
