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Anti-Calcineurin Alpha Antibody (Monoclonal, CN-A1)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P63100 |
| Host | Mouse |
| Isotype | Mouse IgG1 |
| Reactivity | Human, Rat |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Mouse IgG monoclonal antibody for Calcineurin alpha, protein phosphatase 3, regulatory subunit B, alpha (PPP3R1) detection. Tested with WB, IHC-P in Human;bovine;rat. No cross reactivity with other proteins. |
| Gene ID | 29748 |
|---|---|
| Other Names | Calcineurin subunit B type 1, Protein phosphatase 2B regulatory subunit 1, Protein phosphatase 3 regulatory subunit B alpha isoform 1, Ppp3r1, Cna2, Cnb |
| Calculated MW | 19300 MW KDa |
| Application Details | Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, bovine, rat, By Heat Western blot, 0.25-0.5 µg/ml, Human, bovine, rat |
| Subcellular Localization | Cytoplasm, cytosol . Cell membrane ; Lipid-anchor . Cell membrane, sarcolemma. Translocates from the cytosol to the sarcolemma in a CIB1- dependent manner during cardiomyocytes hypertrophy. . |
| Tissue Specificity | Isoform 2 is testis specific. . |
| Protein Name | Calcineurin subunit B type 1 |
| Contents | Each vial contains 50% glycerol, 1.2% Sodium acetate, 1% BSA, 0.02% NaN3. |
| Clone Names | CN-A1 |
| Immunogen | Bovine brain calcineurin. |
| Purification | Ascites |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year, at 4˚C for one month. Avoid repeated freezing and thawing. |
| Sequence Similarities | Belongs to the calcineurin regulatory subunit family. |
| Name | Ppp3r1 |
|---|---|
| Synonyms | Cna2, Cnb |
| Function | Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q63810}. Cell membrane {ECO:0000250|UniProtKB:Q63810}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q63810}. Cell membrane {ECO:0000250|UniProtKB:P63098}; Lipid-anchor {ECO:0000250|UniProtKB:P63098}. Note=Translocates from the cytosol to the sarcolemma in a CIB1-dependent manner during cardiomyocyte hypertrophy. {ECO:0000250|UniProtKB:Q63810} |
| Tissue Location | Isoform 2 is testis specific. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Calcineurin, the Ca(2+)/calmodulin-regulated protein phosphatase, first detected in skeletal muscle and brain, has been found in all cells from yeast to mammals. Calcineurin A alpha(PPP3CA),is located on human chromosomes 4, Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase(calcineurin) catalytic subunit. Calcineurin regulates bone formation by the osteoblast.
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