|Other Accession||NP_067076.2, NP_742013.1, 56658, 79263 (mouse)|
|Predicted||Human, Mouse, Rat, Pig, Dog|
|Calculated MW||59690 Da|
|Other Names||E3 ubiquitin-protein ligase TRIM39, 6.3.2.-, RING finger protein 23, Testis-abundant finger protein, Tripartite motif-containing protein 39, TRIM39, RNF23, TFP|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RNF23 / TRIM39 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||[Isoform 1]: E3 ubiquitin-protein ligase (PubMed:22529100). May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly- ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (PubMed:19100260, PubMed:22529100). Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (PubMed:23213251). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex- mediated CDKN1A/p21 ubiquitination and degradation (PubMed:23213251).|
|Cellular Location||[Isoform 1]: Cytoplasm, cytosol. Mitochondrion. Nucleus Note=Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1. Colocalizes with CDKN1A in the nucleus.|
|Tissue Location||Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognise both reported isoforms (NP_067076.2 and NP_742013.1).
Molecular cloning of testis-abundant finger Protein/Ring finger protein 23 (RNF23), a novel RING-B box-coiled coil-B30.2 protein on the class I region of the human MHC. Orimo A, Yamagishi T, Tominaga N, Yamauchi Y, Hishinuma T, Okada K, Suzuki M, Sato M, Nogi Y, Suzuki H, Inoue S, Yoshimura K, Shimizu Y, Muramatsu M. Biochem Biophys Res Commun. 2000 Sep 16;276(1):45-51. PMID: 11006080
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