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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   Goat Antibodies   >   FOXD1 / FREAC4 / FKHL8 Antibody (C-Term)   

FOXD1 / FREAC4 / FKHL8 Antibody (C-Term)

Peptide-affinity purified goat antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16676
Other Accession NP_004463.1, 2297, 15229 (mouse)
Predicted Human, Mouse, Rat
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Additional Information
Other Names Forkhead box protein D1, Forkhead-related protein FKHL8, Forkhead-related transcription factor 4, FREAC-4, FOXD1, FKHL8, FREAC4
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFOXD1 / FREAC4 / FKHL8 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FOXD1
Synonyms FKHL8, FREAC4
Function Transcription factor involved in regulation of gene expression in a variety of processes, including formation of positional identity in the developing retina, regionalization of the optic chiasm, morphogenesis of the kidney, and neuralization of ectodermal cells (By similarity). Involved in transcriptional activation of PGF and C3 genes (PubMed:27805902).
Cellular Location Nucleus. EMBL; U59831; AAC50660.1; -; Genomic_DNA EMBL; U59832; AAC50661.1; -; mRNA EMBL; U13222; AAA92039.1; -; mRNA CCDS; CCDS75259.1; - PIR; G02738; G02738 PIR; S51627; S51627 RefSeq; NP_004463.1; NM_004472.2 SMR; Q16676; - BioGrid; 108586; 3 STRING; 9606.ENSP00000481581; - iPTMnet; Q16676; - PhosphoSitePlus; Q16676; - BioMuta; FOXD1; - DMDM; 2494490; - jPOST; Q16676; - MassIVE; Q16676; - PaxDb; Q16676; - PeptideAtlas; Q16676; - PRIDE; Q16676; - ProteomicsDB; 61032; - Antibodypedia; 62630; 205 antibodies DNASU; 2297; - Ensembl; ENST00000615637; ENSP00000481581; ENSG00000251493 GeneID; 2297; - KEGG; hsa:2297; - UCSC; uc032uyj.2; human CTD; 2297; - DisGeNET; 2297; - GeneCards; FOXD1; - HGNC; HGNC:3802; FOXD1 HPA; ENSG00000251493; Tissue enhanced (retina) MIM; 601091; gene neXtProt; NX_Q16676; - OpenTargets; ENSG00000251493; - PharmGKB; PA28219; - eggNOG; KOG2294; Eukaryota eggNOG; COG5025; LUCA GeneTree; ENSGT00940000161645; - HOGENOM; CLU_040357_5_1_1; - InParanoid; Q16676; - KO; K09397; - OMA; EVAQMHD; - OrthoDB; 1270467at2759; - SignaLink; Q16676; - ChiTaRS; FOXD1; human GenomeRNAi; 2297; - Pharos; Q16676; Tbio PRO; PR:Q16676; - Proteomes; UP000005640; Chromosome 5 RNAct; Q16676; protein Bgee; ENSG00000251493; Expressed in pigmented layer of retina and 115 other tissues Genevisible; Q16676; HS GO; GO:0000790; C:nuclear chromatin; ISA:NTNU_SB GO; GO:0005634; C:nucleus; IBA:GO_Central GO; GO:0003677; F:DNA binding; IDA:MGI GO; GO:0008301; F:DNA binding, bending; IDA:UniProtKB GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:ProtInc GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central GO; GO:0007411; P:axon guidance; IEA:Ensembl GO; GO:0030154; P:cell differentiation; IBA:GO_Central GO; GO:0060678; P:dichotomous subdivision of terminal units involved in ureteric bud branching; ISS:UniProtKB GO; GO:0032275; P:luteinizing hormone secretion; IEA:Ensembl GO; GO:0072213; P:metanephric capsule development; ISS:UniProtKB GO; GO:0072267; P:metanephric capsule specification; ISS:UniProtKB GO; GO:0072210; P:metanephric nephron development; IEA:Ensembl GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB GO; GO:0072076; P:nephrogenic mesenchyme development; IEA:Ensembl GO; GO:0030513; P:positive regulation of BMP signaling pathway; ISS:UniProtKB GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB GO; GO:0090184; P:positive regulation of kidney development; ISS:UniProtKB GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central CDD; cd00059; FH; 1 Gene3D;; -; 1 InterPro; IPR001766; Fork_head_dom InterPro; IPR018122; TF_fork_head_CS_1 InterPro; IPR030456; TF_fork_head_CS_2 InterPro; IPR036388; WH-like_DNA-bd_sf InterPro; IPR036390; WH_DNA-bd_sf Pfam; PF00250; Forkhead; 1 PRINTS; PR00053; FORKHEAD SMART; SM00339; FH; 1 SUPFAM; SSF46785; SSF46785; 1 PROSITE; PS00657; FORK_HEAD_1; 1 PROSITE; PS00658; FORK_HEAD_2; 1 PROSITE; PS50039; FORK_HEAD_3; 1 1: Evidence at protein level; DNA-binding; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation CHAIN 1..465 /note="Forkhead box protein D1" /id="PRO_0000091811" DNA_BIND 124..215 /note="Fork-head" /evidence="ECO:0000255|PROSITE-ProRule:PRU00089" COMPBIAS 26..34 /note="Poly-Glu" COMPBIAS 39..43 /note="Poly-Gly" COMPBIAS 52..57 /note="Poly-Arg" COMPBIAS 69..72 /note="Poly-Glu" COMPBIAS 73..76 /note="Poly-Asp" COMPBIAS 97..113 /note="Poly-Gly" COMPBIAS 231..234 /note="Poly-Ala" COMPBIAS 252..256 /note="Poly-Ala" COMPBIAS 259..266 /note="Poly-Pro" COMPBIAS 293..303 /note="Poly-Ala" COMPBIAS 309..315 /note="Poly-Pro" COMPBIAS 375..390 /note="Poly-Ala" COMPBIAS 428..434 /note="Poly-Ala" VARIANT 55 /note="R -> P (in dbSNP:rs775281482)" /evidence="ECO:0000269|PubMed:27805902" /id="VAR_077596" VARIANT 88 /note="A -> G (in dbSNP:rs7705335)" /evidence="ECO:0000269|PubMed:27805902" /id="VAR_077597" VARIANT 228 /note="P -> L (in dbSNP:rs562222810)" /evidence="ECO:0000269|PubMed:27805902" /id="VAR_077598" VARIANT 326 /note="A -> T (in dbSNP:rs552595262)" /evidence="ECO:0000269|PubMed:27805902" /id="VAR_077599" VARIANT 336 /note="A -> V (in dbSNP:rs1039708369)" /evidence="ECO:0000269|PubMed:27805902" /id="VAR_077600" VARIANT 352 /note="P -> R (in dbSNP:rs951256776)" /evidence="ECO:0000269|PubMed:27805902" /id="VAR_077601" VARIANT 356 /note="A -> G (polymorphism; decreased activation of transcription from PGF and C3 promoters; dbSNP:rs917127030)" /evidence="ECO:0000269|PubMed:27805902" /id="VAR_077602" VARIANT 364 /note="I -> M (polymorphism; increased activation of transcription from the C3 promoter but no effect on the PGF promoter; dbSNP:rs992724147)" /evidence="ECO:0000269|PubMed:27805902" /id="VAR_077603" VARIANT 383..387 /note="Missing" /evidence="ECO:0000269|PubMed:27805902" /id="VAR_077604" VARIANT 396 /note="P -> L (in dbSNP:rs540644822)" /evidence="ECO:0000269|PubMed:27805902" /id="VAR_077605" VARIANT 437 /note="V -> I" /evidence="ECO:0000269|PubMed:27805902" /id="VAR_077606" VARIANT 442 /note="A -> S" /evidence="ECO:0000269|PubMed:27805902" /id="VAR_077607" SEQUENCE 465 AA; 46140 MW; D3E7854909CCBFAE CRC64; MTLSTEMSDA SGLAEETDID VVGEGEDEED EEEEDDDEGG GGGPRLAVPA QRRRRRRSYA GEDELEDLEE EEDDDDILLA PPAGGSPAPP GPAPAAGAGA GGGGGGGGAG GGGSAGSGAK NPLVKPPYSY IALITMAILQ SPKKRLTLSE ICEFISGRFP YYREKFPAWQ NSIRHNLSLN DCFVKIPREP GNPGKGNYWT LDPESADMFD NGSFLRRRKR FKRQPLLPPN AAAAESLLLR GAGAAGGAGD PAAAAALFPP APPPPPHAYG YGPYGCGYGL QLPPYAPPSA LFAAAAAAAA AAAFHPHSPP PPPPPHGAAA ELARTAFGYR PHPLGAALPG PLPASAAKAG GPGASALARS PFSIESIIGG SLGPAAAAAA AAQAAAAAQA SPSPSPVAAP PAPGSSGGGC AAQAAVGPAA ALTRSLVAAA AAAASSVSSS AALGTLHQGT ALSSVENFTA RISNC
Research Areas
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Characterization of the human forkhead gene FREAC-4. Evidence for regulation by Wilms' tumor suppressor gene (WT-1) and p53. Ernstsson S, Pierrou S, Hulander M, Cederberg A, Hellqvist M, Carlsson P, Enerback S. J Biol Chem. 1996 Aug 30;271(35):21094-9. PMID: 8702877

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$ 368.00
Cat# AF2346a
Availability: 7-10 days
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