GRASP1 / GRIPAP1 Antibody (N-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
---|---|
Primary Accession | Q4V328 |
Other Accession | NP_064522.3, NP_997555.1, 56850 |
Predicted | Human |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 96006 Da |
Gene ID | 56850 |
---|---|
Other Names | GRIP1-associated protein 1, GRASP-1, GRIPAP1, KIAA1167 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GRASP1 / GRIPAP1 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GRIPAP1 (HGNC:18706) |
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Synonyms | KIAA1167 |
Function | Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity- induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity). |
Cellular Location | Early endosome membrane; Peripheral membrane protein. Recycling endosome membrane {ECO:0000250|UniProtKB:Q9JHZ4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JHZ4}. Cell projection, axon {ECO:0000250|UniProtKB:Q9JHZ4}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9JHZ4}. Synapse {ECO:0000250|UniProtKB:Q9JHZ4} Note=Localizes to recycling endosomal tubules that are emanating from early endosomes. {ECO:0000250|UniProtKB:Q9JHZ4} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize both reported isoforms (as represented by NP_064522.3; NP_997555.1)
References
GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex. Ye B, Liao D, Zhang X, Zhang P, Dong H, Huganir RL. Neuron. 2000 Jun;26(3):603-17. PMID: 10896157
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