|Other Accession||NP_115977.2, 84676|
|Predicted||Human, Mouse, Rat, Dog, Cow|
|Calculated MW||40248 Da|
|Other Names||E3 ubiquitin-protein ligase TRIM63, 6.3.2.-, Iris RING finger protein, Muscle-specific RING finger protein 1, MuRF-1, MuRF1, RING finger protein 28, Striated muscle RING zinc finger protein, Tripartite motif-containing protein 63, TRIM63, IRF, MURF1, RNF28, SMRZ|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MURF1 / TRIM63 (internal) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||IRF, MURF1, RNF28, SMRZ|
|Function||E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.|
|Cellular Location||Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere, Z line Note=Colocalizes with TNNI3 in myocytes (By similarity). Localizes to the M- and Z-lines in skeletal muscle.|
|Tissue Location||Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris|
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Provided below are standard protocols that you may find useful for product applications.
Ubiquitin-protein ligases in muscle wasting. Cao PR, Kim HJ, Lecker SH. Int J Biochem Cell Biol. 2005 Oct;37(10):2088-97. Epub 2004 Dec 14. PMID: 16125112
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