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SNM1 / DCLRE1A (internal) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
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- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q6PJP8 |
| Other Accession | NP_055696.3, 9937 |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 116400 Da |
| Gene ID | 9937 |
|---|---|
| Other Names | DNA cross-link repair 1A protein, SNM1 homolog A, hSNM1, hSNM1A, DCLRE1A, KIAA0086, SNM1, SNM1A |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SNM1 / DCLRE1A (internal) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DCLRE1A |
|---|---|
| Synonyms | KIAA0086, SNM1, SNM1A |
| Function | May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (PubMed:31434986). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (PubMed:31434986). |
| Cellular Location | Nucleus. Note=In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross-linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11, RAD50 and NBN) and BRCA1 |
| Tissue Location | Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress. Akhter S, Richie CT, Deng JM, Brey E, Zhang X, Patrick C Jr, Behringer RR, Legerski RJ. Mol Cell Biol. 2004 Dec;24(23):10448-55. PMID: 15542852
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