|Other Accession||NP_115571.1, NP_620305.1, 6651, 20658 (mouse), 304092 (rat)|
|Predicted||Human, Mouse, Rat, Dog, Cow|
|Calculated MW||263830 Da|
|Other Names||Protein SON, Bax antagonist selected in saccharomyces 1, BASS1, Negative regulatory element-binding protein, NRE-binding protein, Protein DBP-5, SON3, SON, C21orf50, DBP5, KIAA1019, NREBP|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SON Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C21orf50, DBP5, KIAA1019, NREBP|
|Function||RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680).|
|Cellular Location||Nucleus speckle. Note=Colocalizes with the pre-mRNA splicing factor SRSF2|
|Tissue Location||Widely expressed, with the higher expression seen in leukocyte and heart|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize reported isoforms B ( NP_115571.1) and F (NP_620305.1).
Son is essential for nuclear speckle organization and cell cycle progression. Sharma A, Takata H, Shibahara K, Bubulya A, Bubulya PA, Molecular biology of the cell 2010 Feb 21 (4): 650-63. PMID: 20053686
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