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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat Anti-GABRG2 Antibody (aa384-396) (internal region)
Goat Anti-GABRG2 Antibody (aa384-396) (internal region)
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- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P18507 |
| Other Accession | NP_944494.1, NP_000807.2, NP_944493.2, 29709, 14406, 2566 |
| Reactivity | Human, Mouse, Rat, Pig |
| Predicted | Human, Mouse, Rat, Pig, Cow, Dog |
| Host | Goat |
| Isotype | IgG |
| Calculated MW | 55186 Da |
| Gene ID | 2566 |
|---|---|
| Other Names | Gamma-aminobutyric acid receptor subunit gamma-2, GABA(A) receptor subunit gamma-2, GABRG2 |
| Immunogen | This antibody is expected to recognize all three reported isoforms (NP_944494.1; NP_000807.2; NP_944493.2). |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-GABRG2 Antibody (aa384-396) (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GABRG2 |
|---|---|
| Function | Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:2538761, PubMed:29950725). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:23909897, PubMed:25489750, PubMed:27864268). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (PubMed:23909897, PubMed:25489750). The alpha2/beta2/gamma2 receptor exhibits synatogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). |
| Cellular Location | Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250|UniProtKB:P22723}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P18508} |
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$ 341.00
Cat# AF4302a
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