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Goat Anti-LILRA4 Antibody (C Terminus)

     
  • WB - Goat Anti-LILRA4 Antibody (C Terminus) AF4307a
    AF4307a (2 µg/ml) staining of Human Spleen lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P59901
Other Accession NP_036408.3, 23547
Reactivity Human
Predicted Human
Host Goat
Isotype IgG
Additional Information
Other Names Leukocyte immunoglobulin-like receptor subfamily A member 4, CD85 antigen-like family member G, Immunoglobulin-like transcript 7, ILT-7, CD85g, LILRA4, ILT7
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-LILRA4 Antibody (C Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LILRA4
Function Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades (PubMed:16735691, PubMed:19564354, PubMed:24586760). Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed:26172439). Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed:24586760).
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Detected on plasmacytoid dendritic cells (at protein level). Detected on plasmacytoid dendritic cells, but not on monocytes or B cells. EMBL; AF041261; AAD02203.1; -; mRNA EMBL; AC008746; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AC008984; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC109198; AAI09199.1; -; mRNA EMBL; BI834924; -; NOT_ANNOTATED_CDS; mRNA EMBL; AF283989; AAL36993.1; -; mRNA CCDS; CCDS12890.1; -. [P59901-1] RefSeq; NP_036408.4; NM_012276.4 SMR; P59901; - IntAct; P59901; 2 STRING; 9606.ENSP00000291759; - iPTMnet; P59901; - PhosphoSitePlus; P59901; - BioMuta; LILRA4; - DMDM; 288558815; - jPOST; P59901; - MassIVE; P59901; - PaxDb; P59901; - PeptideAtlas; P59901; - PRIDE; P59901; - ProteomicsDB; 57167; -. [P59901-1] ProteomicsDB; 57168; -. [P59901-2] TopDownProteomics; P59901-1; -. [P59901-1] ABCD; P59901; - Antibodypedia; 32892; 278 antibodies Ensembl; ENST00000291759; ENSP00000291759; ENSG00000239961 Ensembl; ENST00000613813; ENSP00000479979; ENSG00000277092. [P59901-1] Ensembl; ENST00000616790; ENSP00000483846; ENSG00000274185. [P59901-1] Ensembl; ENST00000619832; ENSP00000481073; ENSG00000276798. [P59901-1] GeneID; 23547; - KEGG; hsa:23547; - UCSC; uc002qfj.4; human. [P59901-1] CTD; 23547; - DisGeNET; 23547; - GeneCards; LILRA4; - HGNC; HGNC:15503; LILRA4 HPA; ENSG00000239961; Group enriched (blood, brain, lymphoid tissue) MIM; 607517; gene neXtProt; NX_P59901; - PharmGKB; PA142671546; - eggNOG; ENOG410IKJD; Eukaryota eggNOG; ENOG41116BR; LUCA HOGENOM; CLU_021100_2_0_1; - InParanoid; P59901; - KO; K06512; - OrthoDB; 1000446at2759; - PhylomeDB; P59901; - TreeFam; TF336644; - Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell GeneWiki; LILRA4; - GenomeRNAi; 23547; - Pharos; P59901; Tbio PRO; PR:P59901; - Proteomes; UP000005640; Chromosome 19 RNAct; P59901; protein Bgee; ENSG00000239961; Expressed in cingulate cortex and 220 other tissues ExpressionAtlas; P59901; baseline and differential Genevisible; P59901; HS GO; GO:0032998; C:Fc-epsilon receptor I complex; IDA:UniProtKB GO; GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB GO; GO:0015026; F:coreceptor activity; IDA:UniProtKB GO; GO:0005102; F:signaling receptor binding; IPI:UniProtKB GO; GO:0038095; P:Fc-epsilon receptor signaling pathway; IMP:UniProtKB GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW GO; GO:0032687; P:negative regulation of interferon-alpha production; IMP:UniProtKB GO; GO:0034156; P:negative regulation of toll-like receptor 7 signaling pathway; IMP:UniProtKB GO; GO:0034164; P:negative regulation of toll-like receptor 9 signaling pathway; IMP:UniProtKB GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IMP:UniProtKB Gene3D; 2.60.40.10; -; 4 InterPro; IPR016332; A1B_glyco/leuk_Ig-like_rcpt InterPro; IPR007110; Ig-like_dom InterPro; IPR036179; Ig-like_dom_sf InterPro; IPR013783; Ig-like_fold InterPro; IPR003599; Ig_sub InterPro; IPR003598; Ig_sub2 InterPro; IPR013151; Immunoglobulin Pfam; PF00047; ig; 1 Pfam; PF13895; Ig_2; 2 PIRSF; PIRSF001979; Alpha_1B_glycoprot_prd; 1 SMART; SM00409; IG; 4 SMART; SM00408; IGc2; 3 SUPFAM; SSF48726; SSF48726; 4 PROSITE; PS50835; IG_LIKE; 3 1: Evidence at protein level; Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein; Immunity; Immunoglobulin domain; Innate immunity; Membrane; Nitration; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix SIGNAL 1..23 /evidence="ECO:0000255" CHAIN 24..499 /note="Leukocyte immunoglobulin-like receptor subfamily A member 4" /id="PRO_0000014819" TOPO_DOM 24..446 /note="Extracellular" /evidence="ECO:0000255" TRANSMEM 447..467 /note="Helical" /evidence="ECO:0000255" TOPO_DOM 468..499 /note="Cytoplasmic" /evidence="ECO:0000255" DOMAIN 24..118 /note="Ig-like C2-type 1" DOMAIN 123..213 /note="Ig-like C2-type 2" DOMAIN 224..313 /note="Ig-like C2-type 3" DOMAIN 324..413 /note="Ig-like C2-type 4" MOD_RES 404 /note="Nitrated tyrosine" /evidence="ECO:0000244|PubMed:16777052" CARBOHYD 138 /note="N-linked (GlcNAc...) asparagine" /evidence="ECO:0000255" CARBOHYD 239 /note="N-linked (GlcNAc...) asparagine" /evidence="ECO:0000255" CARBOHYD 279 /note="N-linked (GlcNAc...) asparagine" /evidence="ECO:0000255" CARBOHYD 300 /note="N-linked (GlcNAc...) asparagine" /evidence="ECO:0000255" DISULFID 49..98 /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" DISULFID 143..195 /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" DISULFID 244..295 /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" DISULFID 344..395 /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" VAR_SEQ 1..66 /note="Missing (in isoform 2)" /evidence="ECO:0000303|PubMed:15489334" /id="VSP_038694" VARIANT 27 /note="P -> L (in dbSNP:rs2241384)" /id="VAR_056054" VARIANT 155 /note="I -> V (in dbSNP:rs10419832)" /id="VAR_056055" CONFLICT 3 /note="L -> P (in Ref. 1; AAD02203)" /evidence="ECO:0000305" CONFLICT 7 /note="S -> V (in Ref. 1; AAD02203)" /evidence="ECO:0000305" CONFLICT 9..11 /note="LFF -> ICL (in Ref. 1; AAD02203)" /evidence="ECO:0000305" CONFLICT 235 /note="T -> N (in Ref. 4; BI834924)" /evidence="ECO:0000305" CONFLICT 398 /note="S -> T (in Ref. 1; AAD02203)" /evidence="ECO:0000305" SEQUENCE 499 AA; 55165 MW; 16FDB2A6C458F53B CRC64; MTLILTSLLF FGLSLGPRTR VQAENLPKPI LWAEPGPVIT WHNPVTIWCQ GTLEAQGYRL DKEGNSMSRH ILKTLESENK VKLSIPSMMW EHAGRYHCYY QSPAGWSEPS DPLELVVTAY SRPTLSALPS PVVTSGVNVT LRCASRLGLG RFTLIEEGDH RLSWTLNSHQ HNHGKFQALF PMGPLTFSNR GTFRCYGYEN NTPYVWSEPS DPLQLLVSGV SRKPSLLTLQ GPVVTPGENL TLQCGSDVGY IRYTLYKEGA DGLPQRPGRQ PQAGLSQANF TLSPVSRSYG GQYRCYGAHN VSSEWSAPSD PLDILIAGQI SDRPSLSVQP GPTVTSGEKV TLLCQSWDPM FTFLLTKEGA AHPPLRLRSM YGAHKYQAEF PMSPVTSAHA GTYRCYGSRS SNPYLLSHPS EPLELVVSGA TETLNPAQKK SDSKTAPHLQ DYTVENLIRM GVAGLVLLFL GILLFEAQHS QRSPPRCSQE ANSRKDNAPF RVVEPWEQI
Research Areas
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$ 368.00
Cat# AF4307a
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