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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat Anti-LILRA4 Antibody (C Terminus)
Goat Anti-LILRA4 Antibody (C Terminus)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P59901 |
| Other Accession | NP_036408.3, 23547 |
| Reactivity | Human |
| Predicted | Human |
| Host | Goat |
| Isotype | IgG |
| Calculated MW | 55181 Da |
| Gene ID | 23547 |
|---|---|
| Other Names | Leukocyte immunoglobulin-like receptor subfamily A member 4, CD85 antigen-like family member G, Immunoglobulin-like transcript 7, ILT-7, CD85g, LILRA4, ILT7 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-LILRA4 Antibody (C Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LILRA4 (HGNC:15503) |
|---|---|
| Function | Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as a negative regulator of TLR7 and TLR9 signaling cascades (PubMed:16735691, PubMed:19564354, PubMed:24586760). Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed:26172439). Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed:24586760). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Detected on plasmacytoid dendritic cells (at protein level). Detected on plasmacytoid dendritic cells, but not on monocytes or B cells. |
Research Areas
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Application Protocols
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$ 341.00
Cat# AF4307a
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