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> home > Products > Primary Antibodies > Antibody Collections > Zebrafish > LOC100360880 Antibody - N-terminal region
LOC100360880 Antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | D3ZLB7 |
| Other Accession | XM_002725539, XP_002725585 |
| Reactivity | Human, Mouse, Rat, Zebrafish, Goat, Horse, Bovine, Dog |
| Predicted | Human, Mouse, Rat, Zebrafish, Pig, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 35kDa |
| Gene ID | 100360880 |
|---|---|
| Alias Symbol | Fosb, fra-2, LOC100360880 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-LOC100360880 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | LOC100360880 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Fosb {ECO:0000312|RGD:1308198} |
|---|---|
| Function | Heterodimerizes with proteins of the JUN family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing their transcriptional activity (By similarity). Exhibits transactivation activity in vitro (By similarity). As part of the AP-1 complex, facilitates enhancer selection together with cell-type- specific transcription factors by collaboratively binding to nucleosomal enhancers and recruiting the SWI/SNF (BAF) chromatin remodeling complex to establish accessible chromatin (By similarity). Together with JUN, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (By similarity). Involved in the display of nurturing behavior towards newborns (By similarity). May play a role in neurogenesis in the hippocampus and in learning and memory-related tasks by regulating the expression of various genes involved in neurogenesis, depression and epilepsy (By similarity). Implicated in behavioral responses related to morphine reward and spatial memory (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:P13346}. |
| Tissue Location | Expressed in brain (PubMed:16687504). Expressed in pyramidal cells in CA1 and CA3, in the dentate gyrus and the nucleus accumbens (at protein level) (PubMed:26446228) |
Research Areas
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$ 389.00
Cat# AI10273
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