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Cd248 Antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q91V98 |
| Other Accession | NM_054042, NP_473383 |
| Reactivity | Human, Mouse, Rat, Rabbit, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 82kDa |
| Gene ID | 70445 |
|---|---|
| Alias Symbol | 2610111G01Rik, AI842296, Cd164l1, Tem1 |
| Other Names | Endosialin, Tumor endothelial marker 1, CD248, Cd248, Tem1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Cd248 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Cd248 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Cd248 |
|---|---|
| Synonyms | Tem1 |
| Function | Cell surface glycoprotein involved in various biological processes including angiogenesis, immune response modulation, and tissue remodeling and repair (PubMed:11489895, PubMed:25243742, PubMed:38061240). Participates in pericyte proliferation through positive modulation of the PDGF receptor signaling pathway (PubMed:30986375). Acts as a scaffold for factor X, triggering allosteric changes and the spatial re-alignment of factor X with the TF-factor VIIa complex, thereby enhancing coagulation activation (PubMed:33830628). Modulates the insulin signaling pathway by interacting with insulin receptor/INSR and by diminishing its capacity to be autophosphorylated in response to insulin (PubMed:38061240). Also regulates LPS-induced inflammatory responses in macrophages by favoring production of proinflammatory cytokines (PubMed:33737161). |
| Cellular Location | Membrane; Single-pass type I membrane protein |
| Tissue Location | Expressed in cell lines derived from endothelial cells, embryonic fibroblasts and preadipocytes (PubMed:11489895) Expressed in skeletal muscle by a subset of pericytes (PubMed:25243742). |
Research Areas
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Submit your citation using an Abcepta antibody to
info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Carson-Walter E.B.,et al.Cancer Res. 61:6649-6655(2001).
Opavsky R.,et al.J. Biol. Chem. 276:38795-38807(2001).
Carninci P.,et al.Science 309:1559-1563(2005).
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$ 389.00
Cat# AI14478
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