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SPIN / SPIN1 Antibody (aa111-160)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9Y657 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 30kDa |
| Dilution | ELISA (1:20000), IHC-P (10 µg/ml), WB (1:500-1:1000) |
| Gene ID | 10927 |
|---|---|
| Other Names | Spindlin-1, Ovarian cancer-related protein, Spindlin1, SPIN1, OCR, SPIN |
| Target/Specificity | SPIN1 Antibody detects endogenous levels of total SPIN1 protein. |
| Reconstitution & Storage | Store at -20°C for up to one year. |
| Precautions | SPIN / SPIN1 Antibody (aa111-160) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SPIN1 |
|---|---|
| Synonyms | OCR, SPIN |
| Function | Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell- cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption. |
| Cellular Location | Nucleus. Nucleus, nucleolus |
| Tissue Location | Highly expressed in ovarian cancer tissues. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.
References
Peng Y.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
Zhang H.L.,et al.Chin. Sci. Bull. 45:909-914(2000).
Gao Y.,et al.Biochem. Biophys. Res. Commun. 335:343-350(2005).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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