GLO1 / Glyoxalase I Antibody (aa1-184)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, ICC |
---|---|
Primary Accession | Q04760 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 21kDa |
Dilution | ICC (1:100-1:1000), IHC-P (7.5 µg/ml), WB (1:500-1:3000) |
Gene ID | 2739 |
---|---|
Other Names | Lactoylglutathione lyase, 4.4.1.5, Aldoketomutase, Glyoxalase I, Glx I, Ketone-aldehyde mutase, Methylglyoxalase, S-D-lactoylglutathione methylglyoxal lyase, GLO1 |
Target/Specificity | Human GLO1 / Glyoxalase I |
Reconstitution & Storage | Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. |
Precautions | GLO1 / Glyoxalase I Antibody (aa1-184) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GLO1 |
---|---|
Function | Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (PubMed:20454679, PubMed:9705294, PubMed:23122816). Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (PubMed:19199007). Required for normal osteoclastogenesis (By similarity). |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF- kappa-B. Required for normal osteoclastogenesis.
References
Kim N.-S.,et al.J. Biol. Chem. 268:11217-11221(1993).
Ranganathan S.,et al.J. Biol. Chem. 268:5661-5667(1993).
Ridderstroem M.,et al.Biochem. J. 314:463-467(1996).
Ranganathan S.,et al.Gene 240:149-155(1999).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
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