|Application ||WB, IHC-P, IF, E|
|Calculated MW||83496 Da|
|Dilution||ELISA, IF (10 µg/ml), IHC-P (5 µg/ml), WB|
|Other Names||E4F1, E4F, E4F transcription factor 1, p50E4F, Transcription factor E4F1, Transcription factor E4F, p120E4F, p120e4f transcription factor|
|Target/Specificity||Human E4F1 / E4F|
|Reconstitution & Storage||Protein A purified|
|Precautions||Anti-E4F1 / E4F Antibody (clone 4B10) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.|
|Cellular Location||Nucleus, nucleoplasm. Cytoplasm. Note=A small fraction is detected in the cytoplasm. Excluded from the nucleolus where it is targeted upon CDKN2A overexpression Localizes to the mitotic spindle during embryogenesis|
|Tissue Location||Ubiquitously expressed.|
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