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Anti-CARD14 Antibody (aa291-340)
Rabbit Anti Human Polyclonal Antibody
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- CITATIONS
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- BACKGROUND
Application 
| IHC-P, IF, E |
|---|---|
| Primary Accession | Q9BXL6 |
| Predicted | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 113270 Da |
| Dilution | ELISA, IF, IHC-P (1:50) |
| Gene ID | 79092 |
|---|---|
| Alias Symbol | CARD14 |
| Other Names | CARD14, BIMP2, Card-maguk protein 2, Carma 2, PrP, PSORS2, PSS1, CARMA2 |
| Target/Specificity | CAR14 Antibody detects endogenous levels of total CAR14 protein. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-CARD14 Antibody (aa291-340) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CARD14 |
|---|---|
| Synonyms | CARMA2 |
| Function | Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27113748, PubMed:27071417). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. |
| Cellular Location | [Isoform 1]: Cytoplasm [Isoform 3]: Cytoplasm |
| Tissue Location | Isoform 1 is detected in placenta and epidermal keratinocytes (PubMed:22521418). Isoform 2 is detected in leukocytes and fetal brain (PubMed:22521418). |
Research Areas
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Application Protocols
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