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ALDH2 Antibody
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS: 3
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, FC, IHC-P, E |
|---|---|
| Primary Accession | P05091 |
| Other Accession | NP_000681 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1,Igκ |
| Clone/Animal Names | 138CT22.3.8 |
| Calculated MW | 56381 Da |
| Gene ID | 217 |
|---|---|
| Other Names | Aldehyde dehydrogenase, mitochondrial, ALDH class 2, ALDH-E2, ALDHI, ALDH2, ALDM |
| Target/Specificity | This ALDH2 Monoclonal antibody is generated from mouse immunized with ALDH2 recombinant protein. |
| Dilution | WB~~1:1000 IF~~1:10~50 FC~~1:10~50 IHC-P~~1:50~100 E~~Use at an assay dependent concentration. |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ALDH2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ALDH2 |
|---|---|
| Synonyms | ALDM |
| Function | Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage. |
| Cellular Location | Mitochondrion matrix. |
Provided below are standard protocols that you may find useful for product applications.
Background
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix.
References
Relationship between genetic polymorphisms of ALDH2 and ADH1B and esophageal cancer risk: a meta-analysis. Yang SJ, et al. World J Gastroenterol, 2010 Sep 7. PMID 20806441. Effects of alcohol-drinking behaviour and ADH1B and ALDH2 polymorphisms on basal DNA damage in human mononuclear cells as determined by the comet assay. Weng H, et al. Mutat Res, 2010 Aug 30. PMID 20685249. Evaluation of a brief web-based genetic feedback intervention for reducing alcohol-related health risks associated with ALDH2. Hendershot CS, et al. Ann Behav Med, 2010 Aug. PMID 20652463. Association of genetic polymorphisms of aldehyde dehydrogenase-2 with esophageal squamous cell dysplasia. Zhou YZ, et al. World J Gastroenterol, 2010 Jul 21. PMID 20632450. Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
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