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FUCA2 Antibody
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BTY2 |
| Other Accession | NP_114409.2 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1,k |
| Clone/Animal Names | 234CT20.2.1 |
| Calculated MW | 54067 Da |
| Gene ID | 2519 |
|---|---|
| Other Names | Plasma alpha-L-fucosidase, Alpha-L-fucoside fucohydrolase 2, Alpha-L-fucosidase 2, FUCA2 |
| Target/Specificity | This FUCA2 monoclonal antibody is generated from mouse immunized with FUCA2 recombinant protein. |
| Dilution | WB~~1:500~1000 E~~Use at an assay dependent concentration. |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FUCA2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FUCA2 |
|---|---|
| Function | Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. |
| Cellular Location | Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric cancer cells.
References
Liu, T.W., et al. Proc. Natl. Acad. Sci. U.S.A. 106(34):14581-14586(2009)
Shah, M., et al. Cancer 113(2):336-346(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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