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INA Antibody
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IF, WB, E |
|---|---|
| Primary Accession | Q16352 |
| Other Accession | P23565, P46660, Q08DH7, NP_116116.1 |
| Reactivity | Human, Mouse |
| Predicted | Bovine, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1,k |
| Clone/Animal Names | 257CT7.1.2 |
| Calculated MW | 55391 Da |
| Antigen Region | 290-319 aa |
| Gene ID | 9118 |
|---|---|
| Other Names | Alpha-internexin, Alpha-Inx, 66 kDa neurofilament protein, NF-66, Neurofilament-66, Neurofilament 5, INA, NEF5 |
| Target/Specificity | This INA antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 290-319 amino acids from human INA. |
| Dilution | IHC-P~~1:10~50 IF~~1:10~50 WB~~1:125 E~~Use at an assay dependent concentration. |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | INA Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | INA |
|---|---|
| Synonyms | NEF5 |
| Function | Class-IV neuronal intermediate filament that is able to self- assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NEFL to form the filamentous backbone to which NEFM and NEFH attach to form the cross-bridges. May also cooperate with the neuronal intermediate filament protein PRPH to form filamentous networks (By similarity). |
| Tissue Location | Found predominantly in adult CNS. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons.
References
Leermakers, F.A., et al. Eur. Biophys. J. 39(9):1323-1334(2010)
Martins-de-Souza, D., et al. J Psychiatr Res 43(11):978-986(2009)
Ducray, F., et al. Neurology 72(2):156-161(2009)
Willoughby, V., et al. Appl. Immunohistochem. Mol. Morphol. 16(4):344-348(2008)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
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