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ZWINT Antibody(Ascites)
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O95229 |
| Other Accession | NP_008988.2, NP_001005413.1 |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgM |
| Clone/Animal Names | 422CT4.6.4 |
| Calculated MW | 31293 Da |
| Gene ID | 11130 |
|---|---|
| Other Names | ZW10 interactor, ZW10-interacting protein 1, Zwint-1, ZWINT |
| Target/Specificity | Purified His-tagged ZWINT protein(Fragment) was used to produced this monoclonal antibody. |
| Dilution | WB~~1:500~4000 |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZWINT Antibody(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZWINT |
|---|---|
| Function | Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase. |
| Cellular Location | Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
References
Brendle, A., et al. Eur. J. Cancer 45(3):435-442(2009)
Famulski, J.K., et al. J. Cell Biol. 180(3):507-520(2008)
Morgan, A.R., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B (6), 762-770 (2007) :
Lin, Y.T., et al. Oncogene 25(52):6901-6914(2006)
Kops, G.J., et al. J. Cell Biol. 169(1):49-60(2005)
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