|Application ||WB, E|
|Other Accession||O88506, Q9Z1W9, NP_037365.2|
|Calculated MW||59474 Da|
|Other Names||STE20/SPS1-related proline-alanine-rich protein kinase, Ste-20-related kinase, DCHT, Serine/threonine-protein kinase 39, STK39, SPAK|
|Target/Specificity||Purified His-tagged STK39 protein(Fragment) was used to produced this monoclonal antibody.|
|Format||Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||STK39 Antibody(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation. Phosphorylates RELT.|
|Cellular Location||Cytoplasm. Nucleus. Note=Nucleus when caspase-cleaved.|
|Tissue Location||Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq].
Duarte, J.D., et al. Pharmacogenet. Genomics 20(8):516-519(2010)
Sid, B., et al. J. Physiol. (Lond.) 588 (PT 13), 2315-2328 (2010) :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Balatoni, C.E., et al. Am. J. Pathol. 175(4):1653-1661(2009)
Cunnington, M.S., et al. BMC Med. Genet. 10, 135 (2009) :
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