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AHCY Antibody(Ascites)
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P23526 |
| Other Accession | Q710C4, Q4R596, Q3MHL4, NP_000678.1, NP_001155238.1 |
| Reactivity | Human, Mouse |
| Predicted | Bovine, Monkey, Pig |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgM |
| Clone/Animal Names | 445CT13.3.3 |
| Calculated MW | 47716 Da |
| Antigen Region | 79-110 aa |
| Gene ID | 191 |
|---|---|
| Other Names | Adenosylhomocysteinase, AdoHcyase, S-adenosyl-L-homocysteine hydrolase, AHCY, SAHH |
| Target/Specificity | This AHCY antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 79-110 amino acids from human AHCY. |
| Dilution | WB~~1:1000~8000 E~~Use at an assay dependent concentration. |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | AHCY Antibody(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AHCY |
|---|---|
| Synonyms | SAHH |
| Function | Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (PubMed:10933798). Binds copper ions (By similarity). |
| Cellular Location | Cytoplasm. Melanosome. Nucleus. Endoplasmic reticulum. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Gass, N., et al. J Affect Disord 126 (1-2), 134-139 (2010) :
Giusti, B., et al. Thromb. Haemost. 104(2):231-242(2010)
Levine, A.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(7):1812-1821(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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