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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   VDR Antibody (Ascites)   

VDR Antibody (Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • WB - VDR Antibody (Ascites) AM2082a
    VDR Antibody (Cat. #AM2082a) western blot analysis in MDA-MB453 cell line lysates (35μg/lane).This demonstrates the VDR antibody detected the VDR protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P11473
Other Accession NP_000367.1
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgA
Clone Names 517CT23.5.1
Calculated MW 48289 Da
Additional Information
Gene ID 7421
Other Names Vitamin D3 receptor, VDR, 25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1, VDR, NR1I1
Target/Specificity Purified His-tagged VDR protein(Fragment) was used to produced this monoclonal antibody.
Dilution WB~~1:500~16000
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsVDR Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VDR
Synonyms NR1I1
Function Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:28698609, PubMed:16913708, PubMed:15728261, PubMed:10678179). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (PubMed:28698609). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (PubMed:28698609). Plays a central role in calcium homeostasis (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:28698609}. Cytoplasm. Note=Localizes mainly to the nucleus. Localization to the nucleus is enhanced by vitamin D3
Research Areas
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Background

This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.

References

An, B.S., et al. Mol. Cell. Biol. 30(20):4890-4900(2010)
Elnenaei, M.O., et al. Br. J. Nutr., 1-8 (2010) In press :
Forghani, N., et al. J. Pediatr. Endocrinol. Metab. 23(8):843-850(2010)
Alvarez-Nava, F., et al. J. Pediatr. Endocrinol. Metab. 23(8):773-782(2010)
Jurutka, P.W., et al. Proc. Natl. Acad. Sci. U.S.A. 93(8):3519-3524(1996)

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$ 325.00
Cat# AM2082a
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