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HPRT1 Antibody(Ascites)
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P00492 |
| Other Accession | Q6LDD9, NP_000185.1 |
| Reactivity | Human |
| Predicted | Monkey |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgM |
| Clone/Animal Names | 571CT1.3.4 |
| Calculated MW | 24579 Da |
| Antigen Region | 150-178 aa |
| Gene ID | 3251 |
|---|---|
| Other Names | Hypoxanthine-guanine phosphoribosyltransferase, HGPRT, HGPRTase, HPRT1, HPRT |
| Target/Specificity | This HPRT1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 150-178 amino acids from human HPRT1. |
| Dilution | WB~~1:500~1600 |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HPRT1 Antibody(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HPRT1 |
|---|---|
| Synonyms | HPRT |
| Function | Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway. |
| Cellular Location | Cytoplasm. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.
References
Garcia, M.G., et al. Nucleosides Nucleotides Nucleic Acids 29 (4-6), 301-305 (2010) :
Torres, R.J., et al. Nucleosides Nucleotides Nucleic Acids 29 (4-6), 295-300 (2010) :
Yamada, Y., et al. Nucleosides Nucleotides Nucleic Acids 29 (4-6), 291-294 (2010) :
Zampieri, M., et al. Mech. Ageing Dev. 131(2):89-95(2010)
Kudo, M., et al. Drug Metab. Pharmacokinet. 24(6):557-564(2009)
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