|Application ||WB, E|
|Calculated MW||54306 Da|
|Antigen Region||352-379 aa|
|Other Names||Vitronectin, VN, S-protein, Serum-spreading factor, V75, Vitronectin V65 subunit, Vitronectin V10 subunit, Somatomedin-B, VTN|
|Target/Specificity||This VTN antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 352-379 amino acids from human VTN.|
|Format||Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||VTN Antibody(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.|
|Cellular Location||Secreted, extracellular space.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Chillakuri, C.R., et al. FEBS Lett. 584(15):3287-3291(2010)
Sa E Cunha, C., et al. PLoS Pathog. 6 (5), E1000911 (2010) :
Kellouche, S., et al. Tumour Biol. 31(2):129-139(2010)
Singh, B., et al. Mol. Microbiol. 75(6):1426-1444(2010)
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