|Application ||WB, E|
|Other Accession||Q9R1E9, O19113, P29268, NP_001892.1|
|Predicted||Mouse, Pig, Rat|
|Calculated MW||38091 Da|
|Antigen Region||166-193 aa|
|Other Names||Connective tissue growth factor, CCN family member 2, Hypertrophic chondrocyte-specific protein 24, Insulin-like growth factor-binding protein 8, IBP-8, IGF-binding protein 8, IGFBP-8, CTGF, CCN2, HCS24, IGFBP8|
|Target/Specificity||This CTGF antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 166-193 amino acids from human CTGF.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CTGF Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CCN2, HCS24, IGFBP8|
|Function||Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.|
|Cellular Location||Secreted, extracellular space, extracellular matrix. Secreted|
|Tissue Location||Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq].
Behrens, M.E., et al. Oncogene 29(42):5667-5677(2010)
Cunningham, J.L., et al. Eur. J. Endocrinol. 163(4):691-697(2010)
Ito, Y., et al. Am. J. Physiol. Renal Physiol. 299 (3), F545-F558 (2010) :
Adler, S.G., et al. Clin J Am Soc Nephrol 5(8):1420-1428(2010)
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
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