|Application ||WB, E|
|Other Accession||P46152, Q08369, P70005, NP_002043|
|Predicted||Xenopus, Mouse, Rat|
|Calculated MW||44565 Da|
|Antigen Region||298-328 aa|
|Other Names||Transcription factor GATA-4, GATA-binding factor 4, GATA4|
|Target/Specificity||This GATA4 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 298-328 amino acids from the C-terminal region of human GATA4.|
|Format||Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GATA4 Antibody (C-term) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function (PubMed:24000169, PubMed:27984724). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (PubMed:27984724). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac- specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (PubMed:20081228). Required during testicular development (PubMed:21220346). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (PubMed:15734735).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects. [provided by RefSeq].
Sood, A., et al. Am. J. Respir. Crit. Care Med. 182(9):1098-1104(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
De Luca, A., et al. Clin. Genet. (2010) In press :
Wang, J., et al. Zhonghua Xin Xue Guan Bing Za Zhi 38(5):429-434(2010)
Guida, V., et al. Dis. Markers 28(5):287-292(2010)
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