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HAGH Antibody (C-term) (Ascites)
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q16775 |
| Other Accession | NP_005317.2 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone/Animal Names | 611CT23.6.1 |
| Calculated MW | 33806 Da |
| Antigen Region | 279-308 aa |
| Gene ID | 3029 |
|---|---|
| Other Names | Hydroxyacylglutathione hydrolase, mitochondrial, Glyoxalase II, Glx II, HAGH, GLO2, HAGH1 |
| Target/Specificity | This HAGH antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 279-308 amino acids from the C-terminal region of human HAGH. |
| Dilution | WB~~1:100~1600 E~~Use at an assay dependent concentration. |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HAGH Antibody (C-term) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HAGH |
|---|---|
| Synonyms | GLO2, HAGH1 |
| Function | Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. |
| Cellular Location | [Isoform 1]: Mitochondrion matrix |
| Tissue Location | Expressed in liver and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Two transcript variants encoding different isoforms have been found for this gene.
References
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Limphong, P., et al. Biochemistry 48(23):5426-5434(2009)
Antognelli, C., et al. Cancer Biol. Ther. 6(12):1880-1888(2007)
Xu, Y., et al. J. Biol. Chem. 281(36):26702-26713(2006)
Antognelli, C., et al. Cancer J 12(3):222-228(2006)
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