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Thyroid Hormone Receptor, α2-Isotype Antibody

Affinity purified mouse monoclonal antibody.

     
  • WB - Thyroid Hormone Receptor, α2-Isotype Antibody AN1102
    Western blot of rat hippocampal lysate showing specific immunolabeling of the ~58k TR-α2 protein.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P10827
Reactivity Human, Rat
Predicted Bovine, Mouse, Monkey
Host Mouse
Clonality monoclonal
Isotype IgG1
Clone Names 1330
Calculated MW 58 KDa
Additional Information
Gene ID 7067
Gene Name THRA
Other Names Thyroid hormone receptor alpha, Nuclear receptor subfamily 1 group A member 1, V-erbA-related protein 7, EAR-7, c-erbA-1, c-erbA-alpha, THRA, EAR7, ERBA1, NR1A1, THRA1, THRA2
Target/Specificity Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH.
Dilution WB~~ 1:1000
Format Prepared from mouse ascites by ammonium sulfate precipitation followed by affinity purification on a protein G column.
Antibody Specificity Specific for the ~58k TR-α2 protein.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsThyroid Hormone Receptor, α2-Isotype Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
ShippingBlue Ice
Research Areas
Citations (0)
citation

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Background

Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors, TRα1, TRα2, TRβ1 and TRβ2. TRα1, TRβ1 and TRβ2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).

References

Ambrogini P, Cuppini R, Ferri P, Mancini C, Ciaroni S, Voci A, Gerdoni E, Gallo G (2005) Thyroid hormones affect neurogenesis in the dentate gyrus of adult rat. Neuroendocrinology 81:244-253.
Chan S, Kilby MD (2000) Thyroid hormone and central nervous system development. J Endocrinol 165:1-8.
Constantinou C, Margarity M, Valcana T (2005) Region-specific effects of hypothyroidism on the relative expression of thyroid hormone receptors in adult rat brain. Mol Cell Biochem 278:93-100.

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$ 365.00
Cat# AN1102
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