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CNP (2,3-cyclic nucleotide-3-phosphodiesterase) Antibody
Rabbit polyclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P13233 |
| Reactivity | Human, Mouse, Rabbit |
| Host | rabbit |
| Clonality | polyclonal |
| Calculated MW | 46 KDa |
| Gene ID | 25275 |
|---|---|
| Gene Name | CNP |
| Other Names | 2', 3'-cyclic-nucleotide 3'-phosphodiesterase, CNP, CNPase, Cnp, Cnp1 |
| Target/Specificity | Endogenous rabbit 2,3 cyclic nucleotide-3-phospho-diesterase. |
| Dilution | WB~~ 1:1000 |
| Format | Neat serum |
| Antibody Specificity | Specific for the ~ 46k CNP protein in Western blots |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CNP (2,3-cyclic nucleotide-3-phosphodiesterase) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Shipping | Blue Ice |
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Provided below are standard protocols that you may find useful for product applications.
Background
2,3-cyclic nucleotide-3-phosphodiesterase (CNP) is a membrane bound, microtubule associated protein that is among the most abundant myelin proteins of the CNS. It is thought that CNP may serve as a regulator of tubulin polymerization and of microtubule distribution (Bifulco et al., 2002). It was recently found that CNP may also function as a possible linker protein anchoring microtubules to the plasma membrane via a 13 residue C-terminal CNP fragment (Bifulco et al., 2002, Esposito et al., 2008).
References
Bifulco et al. 2,3-Cyclic nucleotide 3-phosphodiesterase: a membrane bound, microtubule-associated protein and membrane anchor tubulin. PNAS 99:1807-12, 2002
Esposito C, Scrima M, Carotenuto A, Tedeschi A, Rovero P, D’Ebifulco M, D’Errico G, Malfitano AM, D’Ursi AM (2008) Structures and micelle locations of the nonlipidated and lipidated C-terminal anchor of 2,3-Cyclic nucleotide 3-phosphodiesterase. Biochemistry 47(1): 308-319.
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