|Predicted||Chicken, Human, Mouse|
|Calculated MW||68 KDa|
|Other Names||Neurofilament light polypeptide, NF-L, 68 kDa neurofilament protein, Micro glutamic acid-rich protein, Neurofilament triplet L protein, NEFL|
|Target/Specificity||Preparation of bovine spinal cord NF-L.|
|Format||Total IgY fraction|
|Antibody Specificity||Specific for the ~68k Neurofilament L protein in Western blots and works well on frozen sections, cells in tissue culture and on mildly formalin fixed histological sections.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Neurofilament L (NF-L) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H (1). NF-L is the neurofilament light or low molecular weight polypeptide and runs on SDS-PAGE gels at about 68kDa. Antibodies to NF-L are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. Mutations in the protein coding region of the human NF-L gene cause some forms of Charcot-Marie-Tooth disease (2).
Harris, J., Ayyub, C. and Shaw G. (1991) A molecular dissection of the carboxyterminal tails of the major neurofilament subunits NF-M and NF-H. J Neurosci Res 30:47-62.
2. Mersiyanova IV, Perepelov AV, Polyakov AV, Sitnikov VF, Dadali EL, Oparin RB, Petrin
AN and Evgrafov OV. (2000) A new variant of Charcot-Marie-Tooth disease type 2 is
probably the result of a mutation in the neurofilament-light gene. Am. J. Hum. Genet.
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