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Clavesin 1/2 Antibody

Affinity purified rabbit polyclonal antibody

  • WB - Clavesin 1/2 Antibody AN1201
    Western blot of rat hippocampal homogenate showing specific immunolabelingof the ~ 35k clavesin protein.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession A6JFQ6
Reactivity Rat
Predicted Human, Mouse
Host Rabbit
Clonality polyclonal
Calculated MW 35 KDa
Additional Information
Gene ID 366311
Gene Name CLVS1/2
Other Names Clavesin-1, Retinaldehyde-binding protein 1-like 1, Clvs1 {ECO:0000303|PubMed:19651769}
Target/Specificity Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH.
Dilution WB~~ 1:1000
Format Prepared from serum by affinity purification using a column to which the peptide antigen was coupled.
Antibody Specificity Specific for the ~ 35 kDa clavesin 1/2 protein doublet in Western blots ofrat brain lysate. Isoform-specific knock down in cultured hippocampal neurons indicates that thelower and upper bands are clavesin 1 and 2, respectively.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsClavesin 1/2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
ShippingBlue Ice
Research Areas
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Clavesin (clathrin vesicle associated Sec14 protein) is a novel neuron specific protein that has recently been identified and shown to be required for normal morphology of late endosomes and/or lysosomes as lentiviral-mediated knockdown of clavesin in hippocampal neurons causes lysosomal defects (Katoh et al., 2009). Additionally, upregulation of clavesin in human hepatocellular carcinoma has recently been demonstrated thus making it a useful marker for this disease state (Zhao et al., 2008).


Yohei Katoh, Brigitte Ritter, Thomas Gaffry, Francois Blondeau, Stefan Höning and
Peter S. McPherson (2009) the clavesin family: neuron-specific lipid- and clathrin-binding Sec14
proteins regulating lysosomal morphology. Journal of Biological Chemistry Oct
Zhao S, Xu C, Qian H, Lv L, Ji C, Chen C, Zhao X, Zheng D, Gu S, Xie Y, Mao Y (2008)
Cellular retinaldehyde-binding protein-like (CRALBPL), a novel human Sec14p-like gene
that is upregulated in human hepatocellular carcinomas, may be used as a marker for human
hepatocellular carcinomas. DNA Cell Biol. Mar; 27(3):159-63.

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$ 365.00
Cat# AN1201
Availability: 7-10 days
Bulk Size

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