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Clavesin 1/2 Antibody
Affinity purified rabbit polyclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | A6JFQ6 |
| Reactivity | Rat |
| Predicted | Human, Mouse |
| Host | Rabbit |
| Clonality | polyclonal |
| Calculated MW | 35 KDa |
| Gene ID | 366311 |
|---|---|
| Gene Name | CLVS1/2 |
| Other Names | Clavesin-1, Retinaldehyde-binding protein 1-like 1, Clvs1 {ECO:0000303|PubMed:19651769} |
| Target/Specificity | Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH. |
| Dilution | WB~~ 1:1000 |
| Format | Prepared from serum by affinity purification using a column to which the peptide antigen was coupled. |
| Antibody Specificity | Specific for the ~ 35 kDa clavesin 1/2 protein doublet in Western blots ofrat brain lysate. Isoform-specific knock down in cultured hippocampal neurons indicates that thelower and upper bands are clavesin 1 and 2, respectively. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Clavesin 1/2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Shipping | Blue Ice |
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Provided below are standard protocols that you may find useful for product applications.
Background
Clavesin (clathrin vesicle associated Sec14 protein) is a novel neuron specific protein that has recently been identified and shown to be required for normal morphology of late endosomes and/or lysosomes as lentiviral-mediated knockdown of clavesin in hippocampal neurons causes lysosomal defects (Katoh et al., 2009). Additionally, upregulation of clavesin in human hepatocellular carcinoma has recently been demonstrated thus making it a useful marker for this disease state (Zhao et al., 2008).
References
Yohei Katoh, Brigitte Ritter, Thomas Gaffry, Francois Blondeau, Stefan Höning and
Peter S. McPherson (2009) the clavesin family: neuron-specific lipid- and clathrin-binding Sec14
proteins regulating lysosomal morphology. Journal of Biological Chemistry Oct
2;284(40):27646-54.
Zhao S, Xu C, Qian H, Lv L, Ji C, Chen C, Zhao X, Zheng D, Gu S, Xie Y, Mao Y (2008)
Cellular retinaldehyde-binding protein-like (CRALBPL), a novel human Sec14p-like gene
that is upregulated in human hepatocellular carcinomas, may be used as a marker for human
hepatocellular carcinomas. DNA Cell Biol. Mar; 27(3):159-63.
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