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Lysosomal Associated Membrane Protein 1 (LAMP1) Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IF, WB |
|---|---|
| Primary Accession | P11279 |
| Reactivity | Bovine, Human, Mouse, Rat |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG1 |
| Clone Names | 5H6 |
| Calculated MW | 44882 Da |
| Gene ID | 3916 |
|---|---|
| Gene Name | LAMP1 |
| Other Names | Lysosome-associated membrane glycoprotein 1, LAMP-1, Lysosome-associated membrane protein 1, CD107 antigen-like family member A, CD107a, LAMP1 |
| Target/Specificity | Recombinant full length human LAMP1 expressed in and purified from E. coli. |
| Dilution | WB~~ 1:5000 IF~~ 1:2000 |
| Format | Affinity purified from tissue culture supernatant. |
| Antibody Specificity | Specific for the ~100k LAMP1 protein. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Lysosomal Associated Membrane Protein 1 (LAMP1) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Shipping | Blue Ice |
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Provided below are standard protocols that you may find useful for product applications.
Background
Lysosomal Associated Membrane Protein1 (LAMP1) is a protein that is localized primarily in lysosomes but may also be present on late endosomes and the plasma membrane. LAMP1 antibodies are therefore widely used as lysosome markers. It has recently been suggested that lysosomes are activated in microglia in the progression of multiple system atrophy (MSA) and thus play a key role in its pathology (Makioka et al., 2012).
References
Makioka K, Yamazaki T, Takatama M, Nakazato Y, Okamoto K. (2012) Activation and alteration of lysosomes in multiple system atrophy. Neuroreport. Mar 28;23(5):270-6.
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