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FOX1 (A2BP1) Antibody

Mouse monoclonal antibody

     
  • WB - FOX1 (A2BP1) Antibody AN1242
    Western blot of rat cortex lysate showing specific immunolabeling of the ~46/48k FOX1 protein.
    detail
  • IF - FOX1 (A2BP1) Antibody AN1242
    Immunofluorescence of cultured rat neurons showing nuclear and distal cytoplasmic staining of FOX1 in green.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
  • detail
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IF
Primary Accession Q9NWB1
Reactivity Bovine, Human, Mouse, Rat
Host Mouse
Clonality monoclonal
Isotype IgG1
Clone Names 1G10
Calculated MW 46/48 KDa
Additional Information
Gene ID 54715
Gene Name RBFOX1
Other Names RNA binding protein fox-1 homolog 1, Ataxin-2-binding protein 1, Fox-1 homolog A, Hexaribonucleotide-binding protein 1, RBFOX1, A2BP, A2BP1, FOX1, HRNBP1
Target/Specificity Recombinant protein taken from the N-terminus of human FOX1 expressed in and purified from E. Coli.
Dilution WB~~ 1:5000
IF~~ 1:500
Format Affinity purified from tissue culture supernatant.
Antibody Specificity Specific for the ~46/48k FOX1 protein doublet.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFOX1 (A2BP1) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
ShippingBlue Ice
Research Areas
Citations (0)
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Background

FOX1, also known as ataxin-2 binding protein 1 (A2BP1), is a neuron specific RNA-binding protein that has been shown to regulate a wide range of alternative splicing events implicated in neuronal development and maturation including transcription factors and synaptic proteins (Fogel et al., 2012). Defects in FOX1 have also been associated with autism (Martin et al., 2007), attention-deficit hyperactivity disorder (Elia et al., 2010) and schizophrenia (Xu et al., 2008).

References

Elia J, Gai X, Xie HM, Perin JC, Geiger E, Glessner JT, D'arcy M, deBerardinis R, Frackelton E, Kim C, Lantieri F, Muganga BM, Wang L, Takeda T, Rappaport EF, Grant SF, Berrettini W, Devoto M, Shaikh TH, Hakonarson H, White PS. (2010) Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes. Mol Psychiatry. Jun;15(6):637-46.
Fogel BL, Wexler E, Wahnich A, Friedrich T, Vijayendran C, Gao F, Parikshak N, Konopka G, Geschwind DH. (2012) RBFOX1 regulates both splicing and transcriptional networks in human neuronal development. Hum Mol Genet. Oct 1;21(19):4171-86.
Martin CL, Duvall JA, Ilkin Y, Simon JS, Arreaza MG, Wilkes K, Alvarez-Retuerto A, Whichello A, Powell CM, Rao K, Cook E, Geschwind DH. (2007) Cytogenetic and molecular characterization of A2BP1/FOX1 as a candidate gene for autism. Am J Med Genet B Neuropsychiatr Genet. Oct 5;144B(7):869-76.
Xu B, Roos JL, Levy S, van Rensburg EJ, Gogos JA, Karayiorgou M. (2008) Strong association of de novo copy number mutations with sporadic schizophrenia. Nat Genet. Jul;40(7):880-5.

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$ 365.00
Cat# AN1242
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Availability: 7-10 days
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