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Phospho-Ser244 Ribosomal Protein S6 Antibody

Affinity purified rabbit polyclonal antibody

  • WB - Phospho-Ser244 Ribosomal Protein S6 Antibody AN1252
    Western blot of Jurkat cell lysate showing specific immunolabeling of the ~28k rpS6phosphorylated at Ser244 (Control). Phosphospecificity is shown in the second lanewhere immunolabeling is blocked by preadsorption of the phospho-peptide used asantigen (peptide) but not by the corresponding dephosphopeptide (not shown).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P62754
Reactivity Human, Mouse
Predicted Chicken, Pig, Monkey, Rat, Xenopus, Zebrafish
Host Rabbit
Clonality polyclonal
Calculated MW 28 KDa
Additional Information
Gene ID 20104
Gene Name RPS6
Other Names 40S ribosomal protein S6, Phosphoprotein NP33, Rps6
Target/Specificity Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser244 conjugated to KLH.
Dilution WB~~ 1:1000
Format Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.
Antibody Specificity Specific for the ~28k rpS6 protein phosphorylated at Ser244
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPhospho-Ser244 Ribosomal Protein S6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
ShippingBlue Ice
Research Areas
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Ribosomal protein S6 (rpS6) is a crit ical component of the 40 S ribosomal subunit that mediates translation initiation at the 5 ′ -m 7 GpppG cap of mRNA. The rpS6 protein is both cytoplasmic and nuclear localized (Chen and Dittmer 2011). In response to mitogenic stimuli, rpS6 undergoes ordered C-terminal phosphorylation by p70 S6 kinases and p90 ribosomal S6 kinases on four Ser residues (Ser-235, Ser-236, Ser-240, and Ser-244) whose modification potentiates rpS6 cap binding activity (Hutchinson et al., 2011). Additionally, rpS6 phosphorylation and function are highly regulated and have been implicated in the regulation of translational initiation and protein synthesis in response to extracellular stimuli such as TRAIL and gamma interferon (IFN- γ ), as well as upon activation of the phosphatidylinositol 3-kinase (PI3K)–A kt–mTOR pathway (Chen and Dittmer 2011).


Chen W and Dittmer D (2011) Ribosomal protein S6 (RPS6) interacts with the latency-associated nuclear
antigen (LANA) of Kaposi sarcoma associated
herpesvirus (KSHV). J. Virol. 18 9495-9505
Fumagalli S. and Thomas, G. (2000). S6 phosphorylation
and signal transduction. In Translational control
of gene expression (eds. N. Sonenberg et al.), pp.
695-717. Cold Spring Harbor Laboratory Press,
Cold Spring Harbor, NY.
Hutchinson JA, Shanware NP, Chang H, Tibbetts RS
. (2011
) Regulation of ribosomal protein S6
phosphorylation by casein kinase 1 and prot
ein phosphatase 1. J Biol Chem 10:8688-96

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$ 365.00
Cat# AN1252
Availability: 7-10 days
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