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EWS Antibody

Mouse Monoclonal Antibody

     
  • WB - EWS Antibody AN1268
    Western blot of HeLa cell lysate showing specific immunolabeling of the ~85 kDa EWS protein.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession Q01844
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names 5H7
Calculated MW 68478 Da
Additional Information
Gene ID 2130
Gene Name EWSR1
Target/Specificity full length recombinant human EWS expressed in and purified from E. coli.
Dilution WB~~ 1:1000
Format Protein G purified culture supernatant
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsEWS Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
ShippingBlue Ice
Citations (0)

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Background

The Ewing Sarcoma Breakpoint Region 1 (EWSR1) gene encodes the EWS protein, which along with FUS and TAF15 comprises the FET family of RNA-binding proteins.  EWS is primarily expressed in the nucleus, but has also been found in the cytoplasm of secretory cell types (Andersson et al., 2008).  Defects of EWSR1 are known to cause Ewing sarcoma and have been implicated in amyotrophic lateral sclerosis (ALS) (Svetoni et al., 2016).  Recently, EWS has been shown to directly interact with oncogenic ETS transcription factors in the promotion of prostate cancer (Kedage et al., 2016).

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$ 365.00
Cat# AN1268
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