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Mnk2b Antibody

Rabbit Polyclonal Antibody

     
  • WB - Mnk2b Antibody AN1282
    Western blot of HeLa lysate showing specific immunolabeling of the ~47 kDa Mnk2b isoform in the first lane (-). Specificity is shown in the third lane (Mnk2b) where immunolabeling is blocked by preadsorption of the Mnk2b peptide used as the antigen, but not by the Mnk2a peptide in the second lane.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9HBH9
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 51875 Da
Additional Information
Gene ID 2872
Gene Name MKNK2
Target/Specificity Synthetic peptide from the C-terminal region, specific to the human Mnk2b isoform
Dilution WB~~ 1:1000
Format Antigen Affinity Purified from Pooled Serum
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMnk2b Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
ShippingBlue Ice
Research Areas
Citations (0)

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Background

MAP kinase-interacting kinases Mnk1 and Mnk2, are activated by the MAP kinases, ERK and p38 (Waskiewicz et al., 1997).  Additionally, Mnk1 and Mnk2 have been shown to phosphorylate the translation initiation factor eIF4E (Fukunaga and Hunter 1997; Waskiewicz et al., 1997).   Alternative splicing of the MKNK2 gene results in two isoforms with different C-termini: one that has a MAPK-binding domain, Mnk2a, and one that does not, Mnk2b (Parra et al., 2005).  Recent studies have indicated that Mnk2a has tumor suppressive activity while Mnk2b is pro-oncogenic (Maimon et al., 2014).

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$ 365.00
Cat# AN1282
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