|Application ||WB, E|
|Calculated MW||142867 Da|
|Antigen Region||599-628 aa|
|Other Names||Peroxisome biogenesis factor 1, Peroxin-1, Peroxisome biogenesis disorder protein 1, PEX1|
|Target/Specificity||This PEX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 599-628 amino acids from the Central region of human PEX1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PEX1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes.|
|Cellular Location||Cytoplasm. Peroxisome membrane. Note=Associated with peroxisomal membranes|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the AAA ATPase family, a large group of ATPases associated with diverse cellular activities. This protein is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis. Mutations in this gene have been associated with complementation group 1 peroxisomal disorders such as neonatal adrenoleukodystrophy, infantile Refsum disease, and Zellweger syndrome.
Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :
Yik, W.Y., et al. Hum. Mutat. 30 (3), E467-E480 (2009) :
Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Tamura, S., et al. J. Biol. Chem. 281(38):27693-27704(2006)
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