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GGTLC2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q14390 |
| Other Accession | B5MD39, A6NGU5, P36268, P07314, P20735, Q60928, P19440, NP_954578.2 |
| Reactivity | Human |
| Predicted | Mouse, Pig, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 23661 Da |
| Antigen Region | 127-154 aa |
| Gene ID | 91227 |
|---|---|
| Other Names | Gamma-glutamyltransferase light chain 2, Gamma-glutamyltransferase-like protein 4, GGTLC2, GGTL4 |
| Target/Specificity | This GGTLC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-154 amino acids from the Central region of human GGTLC2. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GGTLC2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GGTLC2 |
|---|---|
| Synonyms | GGTL4 |
| Tissue Location | Placenta and sigmoid tissues. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Gamma-glutamyltransferase-1 (GGT1; MIM 612346) is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. Autocatalytic cleavage of the GGT1 precursor polypeptide produces a heavy chain and a light chain that associate with each other to form the functional enzyme. Light chain-only GGTs, such as GGTLC2, contain a region corresponding to the GGT1 light chain, but they lack the membrane-anchoring heavy chain region (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM].
References
Heisterkamp, N., et al. Hum. Genet. 123(4):321-332(2008)
Dunham, I., et al. Nature 402(6761):489-495(1999)
Kawasaki, K., et al. Genome Res. 7(3):250-261(1997)
Leh, H., et al. FEBS Lett. 394(3):258-262(1996)
Wetmore, L.A., et al. Proc. Natl. Acad. Sci. U.S.A. 90(16):7461-7465(1993)
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