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KATL1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q9BW62 |
| Other Accession | NP_115492.1, NP_001014402.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 55392 Da |
| Antigen Region | 137-166 aa |
| Gene ID | 84056 |
|---|---|
| Other Names | Katanin p60 ATPase-containing subunit A-like 1 {ECO:0000255|HAMAP-Rule:MF_03024}, Katanin p60 subunit A-like 1 {ECO:0000255|HAMAP-Rule:MF_03024}, 3643 {ECO:0000255|HAMAP-Rule:MF_03024}, p60 katanin-like 1 {ECO:0000255|HAMAP-Rule:MF_03024}, KATNAL1 {ECO:0000255|HAMAP-Rule:MF_03024} |
| Target/Specificity | This KATL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-166 amino acids from the N-terminal region of human KATL1. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KATL1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KATNAL1 {ECO:0000255|HAMAP-Rule:MF_03024} |
|---|---|
| Function | Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule- severing activity in vitro (PubMed:26929214). |
| Cellular Location | Cytoplasm, cytoskeleton {ECO:0000255|HAMAP- Rule:MF_03024, ECO:0000269|PubMed:22654668}. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Note=Colocalizes with microtubules throughout the basal and adluminal compartments of Sertoli cells (By similarity). Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis (PubMed:26929214). {ECO:0000250|UniProtKB:Q8K0T4, ECO:0000269|PubMed:26929214} |
| Tissue Location | Expressed in testis, restricted to Sertoli cells (at protein level). |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Dunham, A., et al. Nature 428(6982):522-528(2004)
Millar, J.K., et al. Biochem. Biophys. Res. Commun. 311(4):1019-1025(2003)
Robertson, N.G., et al. Genomics 23(1):42-50(1994)
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$ 365.00
$ 140.00
Cat# AP10229a
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