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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   LRRC33 Antibody (C-term)   

LRRC33 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - LRRC33 Antibody (C-term) AP10317b
    LRRC33 Antibody (C-term) (Cat. #AP10317b) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the LRRC33 antibody detected the LRRC33 protein (arrow).
  • IHC-P - LRRC33 Antibody (C-term) AP10317b
    LRRC33 antibody (C-term) (Cat. #AP10317b) immunohistochemistry analysis in formalin fixed and paraffin embedded human lymph node followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the LRRC33 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession Q86YC3
Other Accession NP_940967.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 76366 Da
Antigen Region 611-640 aa
Additional Information
Gene ID 375387
Other Names Negative regulator of reactive oxygen species, Leucine-rich repeat-containing protein 33, NRROS, LRRC33
Target/Specificity This LRRC33 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 611-640 amino acids from the C-terminal region of human LRRC33.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLRRC33 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NRROS (HGNC:24613)
Function Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system (By similarity). Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin- dependent activation of TGF-beta-1 (By similarity). TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS (By similarity). Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling (PubMed:23545260).
Cellular Location Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BMT4}; Single-pass type I membrane protein
Tissue Location Mainly expressed in cells of hematopoietic origin (PubMed:29909984). Highly expressed in bone marrow, thymus, liver, lung, intestine and spleen (PubMed:23545260)
Research Areas
Citations (0)

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References

Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)

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Cat# AP10317b
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