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ACTL7A Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y615 |
| Other Accession | Q4R6Q3, NP_006678.1 |
| Reactivity | Human |
| Predicted | Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 48644 Da |
| Antigen Region | 41-67 aa |
| Gene ID | 10881 |
|---|---|
| Other Names | Actin-like protein 7A, Actin-like-7-alpha, ACTL7A |
| Target/Specificity | This ACTL7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-67 amino acids from the N-terminal region of human ACTL7A. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ACTL7A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ACTL7A |
|---|---|
| Function | May play an important role in formation and fusion of Golgi- derived vesicles during acrosome biogenesis. |
| Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QY84}. Golgi apparatus {ECO:0000250|UniProtKB:Q9QY84}. Cytoplasm {ECO:0000250|UniProtKB:Q9QY84}. Nucleus {ECO:0000250|UniProtKB:Q9QY84} Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Detected at the Golgi apparatus during acrosome biogenesis. Detected at the subacrosomal layer in round spermatids. Detected in sperm head and tail {ECO:0000250|UniProtKB:Q9QY84} |
| Tissue Location | Strongly expressed in testis. Also expressed in other tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ACTL7A is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. ACTL7A (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known.
References
Aberg, K., et al. Hum. Biol. 80(2):99-123(2008)
Humphray, S.J., et al. Nature 429(6990):369-374(2004)
Garvalov, B.K., et al. J. Cell Biol. 161(1):33-39(2003)
Coutts, A.S., et al. J. Cell. Sci. 116 (PT 5), 897-906 (2003) :
Chadwick, B.P., et al. Genomics 58(3):302-309(1999)
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