|Application ||WB, E|
|Other Accession||P63081, P63082, P23380, P23956, P34546, NP_001685.1, O18882, C0HLB3, C0HLB4|
|Predicted||C.Elegans, Bovine, Drosophila, Rat, Sheep|
|Calculated MW||15736 Da|
|Antigen Region||100-126 aa|
|Other Names||V-type proton ATPase 16 kDa proteolipid subunit, V-ATPase 16 kDa proteolipid subunit, Vacuolar proton pump 16 kDa proteolipid subunit, ATP6V0C, ATP6C, ATP6L, ATPL|
|Target/Specificity||This ATP6V0C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 100-126 amino acids from the C-terminal region of human ATP6V0C.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATP6V0C Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ATP6C, ATP6L, ATPL|
|Function||Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.|
|Cellular Location||Vacuole membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
ATP6V0C is a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. ATP6V0C encodes the V0 subunit c.
O'Callaghan, K.M., et al. J. Biol. Chem. 285(1):381-391(2010)
You, H., et al. Cancer Lett. 280(1):110-119(2009)
Lee, I., et al. J. Biol. Chem. 279(51):53007-53014(2004)
Morel, N. Biol. Cell 95(7):453-457(2003)
Smith, A.N., et al. Mol. Cell 12(4):801-803(2003)
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