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ZNF536 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | O15090 |
| Other Accession | NP_055532.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 141417 Da |
| Antigen Region | 203-231 aa |
| Gene ID | 9745 |
|---|---|
| Other Names | Zinc finger protein 536, ZNF536, KIAA0390 |
| Target/Specificity | This ZNF536 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 203-231 amino acids from the N-terminal region of human ZNF536. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZNF536 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZNF536 |
|---|---|
| Synonyms | KIAA0390 |
| Function | Transcriptional repressor that negatively regulates neuron differentiation by repressing retinoic acid-induced gene transcription (PubMed:19398580). Binds and interrupts RARA from binding to retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:19398580). Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3' (PubMed:14621294). |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3'.
References
Benjamin, E.J., et al. BMC Med. Genet. 8 SUPPL 1, S11 (2007) :
Dugas, J.C., et al. J. Neurosci. 26(43):10967-10983(2006)
Sakai, T., et al. DNA Res. 10(4):155-165(2003)
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