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PMAT(Slc29a4) Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - PMAT(Slc29a4) Antibody (N-term) AP1087a
    Western blot analysis of anti-PMAT(Slc29a4) Antibody (N-term) (Cat. #AP1087a) in HepG2 cell line lysates (35ug/lane). PMAT(arrow) was detected using the purified Pab.
    detail
  • IHC-P - PMAT(Slc29a4) Antibody (N-term) AP1087a
    Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with PMAT(Slc29a4) Antibody (N-term) (Cat.#AP1087a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession Q8R139
Other Accession Q7RTT9
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 58099 Da
Antigen Region 39-69 aa
Additional Information
Gene ID 243328
Other Names Equilibrative nucleoside transporter 4, Solute carrier family 29 member 4, Slc29a4, Ent4
Target/Specificity This PMAT(Slc29a4) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-69 amino acids from the N-terminal region of mouse PMAT(Slc29a4).
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPMAT(Slc29a4) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Slc29a4 {ECO:0000312|MGI:MGI:2385330}
Function Electrogenic voltage-dependent transporter that mediates the transport of a variety of endogenous bioactive amines, cationic xenobiotics and drugs (PubMed:16873718, PubMed:23255610). Utilizes the physiologic inside-negative membrane potential as a driving force to facilitate cellular uptake of organic cations (By similarity). Functions as a Na(+)- and Cl(-)-independent bidirectional transporter (By similarity). Substrate transport is pH-dependent and enhanced under acidic condition, which is most likely the result of allosteric changes in the transporter structure (PubMed:16873718). Implicated in monoamine neurotransmitters uptake such as serotonin, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the central nervous system (PubMed:23255610). Also responsible for the uptake of bioactive amines and drugs through the blood-cerebrospinal fluid (CSF) barrier, from the CSF into choroid plexus epithelial cells, thereby playing a significant role in the clearance of cationic neurotoxins, xenobiotics and metabolic waste in the brain (PubMed:23255610). Involved in bidirectional transport of the purine nucleoside adenosine and plays a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia (PubMed:16873718). May be involved in organic cation uptake from the tubular lumen into renal tubular cells, thereby contributing to organic cation reabsorption in the kidney (PubMed:23255610). Also transports adenine and guanidine (PubMed:16873718).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q7RTT9}; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Localized to the apical blood-cerebrospinal fluid(CSF)-facing membrane of the choroid plexus epithelium
Tissue Location Expressed in heart (PubMed:16873718). Expressed in choroid plexus (PubMed:23255610).
Research Areas
Citations (0)
citation

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Background

PMAT(Slc29a4) is a member of the SLC29 family. It is a plasma membrane protein with 11 transmembrane helices. This protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium.

References

Barnes,K., Circ. Res. 99 (5), 510-519 (2006)
Engel,K., J. Biol. Chem. 279 (48), 50042-50049 (2004)

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$ 365.00
$ 140.00
Cat# AP1087a
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