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> home > Products > Primary Antibodies > Antibody Collections > Immune system process > IGKV A18 Antibody (C-term)
IGKV A18 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | A2NJV5 |
| Other Accession | P01631, P06310, P06309, P01617, A0A0C4DH68, A0A075B6P5, A0A087WW87, A0A0A0MRZ7, P01615, A0A075B6S2, A0A075B6S6, P01614, A0A075B6R9 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 13085 Da |
| Antigen Region | 80-107 aa |
| Other Names | IGKV A18 |
|---|---|
| Target/Specificity | This IGKV A18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-107 amino acids from the C-terminal region of human IGKV A18. |
| Dilution | WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | IGKV A18 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IGKV2-29 {ECO:0000303|PubMed:11549845, ECO:0000303|Ref.4} |
|---|---|
| Function | V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins- secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). |
| Cellular Location | Secreted. Cell membrane |
Research Areas
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Application Protocols
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Discontinued
Cat# AP11694b
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